pentobarbital will reduce the extent or influence of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Pitolisant exposure is lessened by fifty% if coadministered with solid CYP3A4 inducers.pentobarbital will lessen the extent or influence of doxorubicin by affecting hepatic/intestinal enzyme CYP3